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Publications

  1. Buck LT, Shin DS (2002). The role of adenosine in the natural anoxia-tolerance of the freshwater turtle.  Trends in Comparative Biochemistry & Physiology. 9:93-116. [Review article].

  2. Shin DS, Ghai H, Cain S, Buck LT (2003). Gap junctions do not underlie changes in whole-cell conductance in anoxic turtle brain.  Comparative Biochemistry and Physiology, Part A. 134(1):179-192. 

  3. Shin DS, Buck LT (2003). Effect of anoxia and pharmacological anoxia on whole-cell NMDA receptor currents in cortical neurons from the western painted turtle. Physiological and Biochemical Zoology. 76(1):41-51.

  4. Shin DS, Wilkie MP, Pamenter ME, Buck LT (2005). Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comparative Biochemistry & Physiology. Part A.  142(1):50-57.

  5. Shin DS, Samoilova M, Cotic M, Zhang L, Brotchie JM, Carlen PL (2007). High frequency stimulation or raised K+ depress neuronal activity in the rat entopeduncular nucleus.  Neuroscience. 149(1):68-86.

  6. Derchansky M, Jahromi SS, Mamani M, Shin DS, Sik A, Carlen PL (2007). The cellular dynamics of spontaneous transition to seizure: more exciting than you think. Clinical Neurophysiology. 118:e183-e188. [Review article].

  7. Shin DS, Carlen PL (2008). Enhanced Ih depresses rat entopeduncular nucleus neuronal activity from high-frequency stimulation or raised K+e. Journal of Neurophysiology. 99(5):2203-2219.

  8. Derchansky M, Shokrollah J, Mamani M, Shin DS, Sik A, Carlen PL (2008). Transition to Seizure: A Switch from Phasic Dominant Inhibition to Dominant Excitation. Journal of Physiology (London).  586(2):477-494.

  9. Pamenter ME, Shin DS, Buck LT (2008). Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. Brain Research. 1213:27

  10. Wilkie MP, Pamenter ME, Alkabie S, Carapic D, Shin DS, Buck LT (2008). Evidence of Anoxia-Induced Channel Arrest in the Brain of the Goldfish (Carassius auratus). Comparative Biochemistry and Physiology. 148:355-362.

  11. Pamenter ME, Shin DS, Cooray M, Buck LT (2008). Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. Journal of Physiology (London). 586(4):1043-1058.

  12. Pamenter ME, Shin DS, Buck LT (2008). AMPA receptors undergo channel arrest in the anoxic turtle cortex. American Journal of Physiology Regulatory and Integrative Comparative Physiology. 294(2):R606-R613.

  13. Shin DS, Yu W, Fawcett A, Carlen PL (2010). Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus. Brain Research. 1331:39-50.

  14. Hamani C, Dubiela FP, Soares JCK, Shin D, Bittencourt S, Covolan L, Carlen P, Laxton AW, Hodaie M, Lozano AM, Mello LE, Oliveria MGM (2010). Anterior thalamus deep brain stimulation at high current impairs memory in rats. Experimental Neurology. 225:154-162.

  15. Shin DS, Yu W, Sutton A, Calos M, Puil E, Carlen PL (2011). Isovaline, a rare amino acid, has anti-convulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity. Epilepsia. 52(11):2084-93.

  16. Shin DS, Yu W, Sutton A, Calos M, Carlen PL (2011).  Elevated potassium elicits recurrent surges of large GABAA-receptor mediated post-synaptic currents in hippocampal CA3 pyramidal neurons. Journal of Neurophysiology. 105(3):1185-98.

  17. Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA, Buck LT (2011). Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance. Proceedings of the National Academy of Sciences. 108(27):11274-9.

  18. Huang X, McMahon J, Yang J, Shin D, Huang Y (2012). Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience. 219:33-47.

  19. Zhang ZJ, Koifman J, Shin DS, Ye H, Florez CM, Zhang L, Valiante TA, Carlen PL (2012). Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region.  Journal of Neuroscience. 32(7):2499-512.

  20. Yu W, Calos M, Pilitsis J, Shin DS (2013). Deconstructing the neural and ionic involvement of seizure-like events in the striatal network.  Neurobiology of Disease. 52:128-136.

  21. Sutton A, Yu WJ, Calos ME, Mueller LE, Berk M, Molho E, Brotchie JM, Carlen PL, Shin DS (2013). Elevated K+ provides an ionic mechanism for deep brain stimulation in the hemiparkinsonian rat.  European Journal of Neuroscience. 37(2):231-241.

  22. Sutton A, Yu WJ, Calos ME, Smith AB, Ramirez-Zamora A, Molho ES, Pilitsis JG, Brotchie JM, Shin DS (2013). Deep brain stimulation of the substantia nigra reticulata improves forelimb akinesia in the hemiparkinsonian rat.  Journal of Neurophysiology. 109(2):363-374.

  23. Pushparaj A, Hamani C, Yu W, Shin DS, Nobrega JN, Le Foll B (2013). Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors. Neuropsychopharmacology. 38(4):690-698.

  24. Campbell JC, Jeyamohan SB, De La Cruz P, Chen N, Shin DS, Pilitsis JG (2014). Place conditioning to apomorphine in rat models of Parkinson’s disease: Differences by dose and side-effect expression. Brain Behavioral Research. 275:114-9 

  25. Yu W, Smith AB, Pilitsis J, Shin D (2014). Isovaline attenuates epileptiform activity and seizure behavior in 4-aminopyridine treated rats.  Epilepsy Research. 108:331-335.

  26. Yu W, Shin DS (2014). Isovaline: a unique amino acid with antiepileptic drug properties.  Molecular and Cellular Epilepsy. 1:110-112. [Review article].

  27. Yu W, Smith AB, Pilitsis JG, Shin DS (2015). Isovaline attenuates generalized epileptiform activity in hippocampal and primary sensory cortices and seizure behavior in pilocarpine treated rats. Neuroscience Letters. 599:125-128.

  28. Phookan S, Sutton AC, Walling I, Smith A, O’Connor KA, Campbell J, Calos M, Yu W, Pilitsis JG, Brotchie J, Shin DS (2015). Gap junction blockers attenuate beta oscillations and improve forelimb function in hemiparkinsonian rats. Experimental Neurology, 265:160-70.

  29. Smith H, Gee L, Vignessh K, Ramirez-Zamora A, Durphy J, Hanspal E, Barba A, Molho E, Shin D, Pilitsis JG (2015). Deep brain stimulation significantly decreases disability from low back pain in patients with advanced Parkinson’s disease. Stereotactic and Functional Neurosurgery. 93(3):206-211.

  30. Gee LE, Chen N, Ramirez-Zamora A, Shin DS#, Pilitsis JG# (2015). The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA lesioned rats. European Journal of Neuroscience. 42:2061-2069. #Co-mentors.

  31. Sutton AC, O’Connor K, Pilitsis JG, Shin DS (2015). Deep brain stimulation of the subthalamic nucleus engages the cerebellum to provide therapeutic efficacy in hemiparkinsonian rats. Brain Structure and Function. 220(6): 3595-3609.

  32. Gee L, Smith H, De La Cruz P, Campbell J, Fama C, Haller J, Ramirez-Zamora A, Durphy J, Hanspal E, Molho E, Barba A, Shin D, Pilitsis JG (2015). The influence of bilateral subthalamic nucleus deep brain stimulation on impulsivity and prepulse inhibition in Parkinson’s disease patients. Stereotactic and Functional Neurosurgery. 93(4):265-70.

  33. De La Cruz P, Gee L, Walling I, Morris B, Chen N, Kumar V, Feustel P, Shin D, Pilitsis JG (2015). Treatment of allodynia by occipital nerve stimulation in chronic migraine rodent. Neurosurgery. 77(3):479-85.

  34. McMahon JJ, Yu W, Yang J, Feng H, Helm M, McMahon E. Zhu X, Shin D, Huang Y (2015). Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice. Neurobiology of Disease. 73C:296-306.

  35. Yu W, Walling I, Smith AB, Ramirez-Zamora A, Pilitsis JG, Shin DS (2016). Deep brain stimulation of the ventral pallidum attenuates epileptiform activity and seizing behavior in pilocarpine-treated rats. Brain Stimulation. 9(2):285-295.

  36. O’Connor KA, Feustel PJ, Molho E, Ramirez-Zamora A, Pilitsis JG, Shin DS (2016). Investigation of diazepam efficacy on anxiety-like behavior in hemiparkinsonian rats. Behavioral Brain Research. 301:226-237.

  37. Ramirez-Zamora, A, Gee L, Youn Y, Shin DS, Pilitsis JG (2016). Pallidal deep brain stimulation for the treatment of juvenile L-dopa-responsive dystonia and parkinsonism secondary to spasctin mutation (SPG11). JAMA Neurology.  74(1):127-128.

  38. Ramirez-Zamora A, Kaszuba B, Gee L, Prusik J, Molho E, Wilock M, Shin D, Pilitsis JG (2016). Clinical outcome and intraoperative neurophysiology for focal limb dystonic tremor without generalized dystonia treated with deep brain stimulation. Clinical Neurology and Neurosurgery. 150:169-176.

  39. Ramirez-Zamora A, Kaszuba B, Gee L, Prusik J, Danisi F, Shin D, Pilitsis JG (2016). Clinical outcome and characterization of local field potentials in Holmes tremor treated with pallidal deep brain stimulation. Tremor and other Hyperkinetic Movements. 6:388.

  40. Gee LE, Walling I, Ramirez-Zamora A, Shin DS#, Pilitsis JG# (2016). Subthalamic deep brain stimulation alters neuronal firing in canonical pain nuclei in a 6-hydroxydopamine lesioned rat model of Parkinson’s disease. Experimental Neurology, 283:298-307. #Co-mentors.

  41. Ramirez-Zamora A, Smith H, Youn Y, Durphy J, Shin D, Pilitsis JG (2016). Hyperhydrosis associated with subthalamic deep brain stimulation in Parkinson’s disease; insights into central autonomic functional anatomy. Journal of Neurological Sciences. 366:59-64.

  42. Belasen A, Youn Y, Prusik J, Lai B, Ramirez-Zamora A, Gee L, Rizvi K, Yeung P, Shin DS, Argoff C, Pilitsis JG (2016). The effects of mechanical and thermal stimuli on local field potentials in Parkinson’s disease patients. Neurmodulation: Technology at the Neural Interface. 19(7):698-707.

  43. O’Connor KA, Mahoney E, Ramirez-Zamora A, Molho E, Pilitsis JG, Shin DS (2017). Effect of diazepam and yohimbine on neuronal activity in sham and hemiparkinsonian rats. Neuroscience. 351:71-83.

  44. Walling I, Smith H, Gee LE, Kaszuba B, Chockalingam A, Barborica A, Donos C, Shin DS, Pilitsis JG (2017). Occipital nerve stimulation attenuates neuronal firing response to mechanical stimuli in the ventral posteriomedial thalamus of a rodent model of chronic migraine. Neurosurgery. 81(4):696-701.

  45. Chockalingam A, Belasen A, Chen N, Ramirez-Zamora A, Youn Y, Feustel P, Wilock ME, Shin DS, Pilitsis JG (2017). Effect of eye opening on single-unit activity and local field potentials in the subthalamic nucleus. Neuromodulation: Technology at the Neural Interface. 20(5): 471-477.

  46. Kaszuba BC, Walling I, Gee LE, Shin DS, Pilitsis JG (2017). Effects of subthalamic deep brain stimulation with duloxetine on mechanical and thermal thresholds in 6OHDA lesioned rats. Brain Research. 1655:233-241.

  47. Mahoney E, Zeng A, Yu W, Rowe M, Sahai S, Feustel PJ, Ramirez-Zamora A, Pilitsis JG, Shin DS (2018). Ventral pallidum deep brain stimulation attenuates acute partial, generalized and tonic-clonic seizures in two rat models. Epilepsy Research. 142:36-44.

  48. Walling I, Panse D, Gee L, Maietta T, Kaszuba B, Kumar V, Gannon S, Hellman A, Neubauer P, Frith L, Williams E, Ghoshal G, Shin DS, Burdette C, Qian J, Pilitsis JG (2018). The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine. Brain Research. 1699:135-141.

  49. Ramirez-Zamora A, Eisinger RS, Haider S, Youn Y, Shin D, Molho E, Pilitsis JG (2018). Pallidal DBS and intraoperative neurophysiology for treatment of Post-Stroke Hemiballism. Annals of Clinical and Translational Neurology. 5(7):865-869.

  50. Tucker H, Mahoney E, Chhetri A, Unger K, Mamone G, Kim G, Audil A, Moolick B, Molho ES, Pilitsis JG, Shin DS (2019). Deep brain stimulation of the ventroanterior and ventrolateral thalamus improves motor function in rat model of Parkinson’s disease. Experimental Neurology. 317:155-167.

  51. Kaszuba BC, Maietta T, Walling I, Feutel P, Stapleton A, Shin DS, Slyer J, Pilitsis JG (2019). Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats. Brain Research. 1715:66-72.

  52. Dimarzio M, Rashid T, Hancu I, Fiveland E, Prusik J, Gillogly M, Madhavan R, Joel J, Durphy J, Molho E, Hanspal E, Shin D, Pilitsis JG (2019). Functional MRI signature of chronic pain relief from deep brain stimulation in Parkinson's disease patients. Neurosurgery. 85(6):E1043-E1049. *Selected as 2020 Pain Paper of the Year Award by Neurosurgery.

  53. Sahai S#, Effendi ET#, Mahoney EC, Tucker HR, Moolick BJ, Mamone G, Mikkilineni S, Gupta M, Nicholson A, Chua FY, Akhtar K, Hirschstein Z, Molho ES, Pilitsis JG, Shin DS (2020). Effects of subthalamic nucleus deep brain stimulation on neuronal spiking activity in the substantia nigra pars compacta in a rat model of Parkinson’s disease. Neuroscience Letters. 739: 135443. #contributed equally.

  54. Dimarzio M, Madhavan R, Hancu I, Fiveland E, Prusik J, Suresh J, Gillogly M, Telkes I, Staudt MD, Durphy J, Shin D, Pilitsis JG (2020). Use of functional MRI to assess effects of deep brain stimulation frequency changes on brain activation in Parkinson Disease. Neurosurgery. 88(2):356-365.

  55. Dimarzio M, Madhavan R, Suresh J, Hancu I, Fiveland E, Prusik J, Gillogly M, Tanweer R, MacDonell J, Ashe J, Telkes I, Feustel P, Staudt MD, Shin DS, Durphy J, Hwang R, Hanspal E, Pilitsis JG (2020). Use of functional MRI to assess how motor phenotypes of Parkinson's Disease respond to DBS. Neuromodulation: Technology at the Neural Interface. 23(4): 515-524.

  56. Hellman A, Maietta T, Byraju K, Park YL, Liss A, Prabhala T, Neubauer P, Williams E, Burdette C, Shin DS, Ghoshal G, Nalwalk J, Agrawal A, Qian J, Pilitsis J (2020). Effects of external low intensity focused ultrasound on electrophysiological changes in vivo in a rodent model of common peroneal nerve injury. Neuroscience. 429:264-272.

  57. Tucker HR#, Mahoney E#, Akhtar K, Kao T-J, Mamone G,  Mikkilineni S, Ravi M, Watkins H, Terrelonge D-L, Martin C, Unger K, Kim G, Fiber K, Gupta M, Indajang J, Kochman EM, Sachs N, Feustel P, Molho ES, Pilitsis JG, Shin DS (2021). Motor thalamic deep brain stimulation alters cortical activity and shows therapeutic utility for treatment of Parkinson’s disease symptoms in a rat model. Neuroscience. 460: 88-106. #contributed equally.

  58. Akhtar K#, Hirschstein Z#, Stefanelli A, Iannilli E, Srinivasan A, Barenboim L, Balkaya M, Cunha A, Audil A, Kochman EM, Chua FY, Ravi M, Mikkilineni S, Watkins H, O’Connor Jr. W, Fan Y, Cotero V, Ashe J, Puleo C, Kao T-J, Shin DS (2021). Non-invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease. Experimental Physiology. 106: 1038-1060. #contributed equally.

  59. Fung I, Zhang Y, Shin DS, Sankar P, Sun X, D’Souza S, Song R, Kuentzel M, Chittur S, Zuloaga KL, Yang Q (2021). Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer’s disease. J Neuroinflammation. 18(1):152-166.

  60. Kochman, EM, Akhtar K, Alelayawi A, Shin DS (2021). Clinical and pre-clinical evidence for enteric alpha-synuclein involvement in Parkinson’s disease. International Journal of Neurodegenerative Disorders. 4(1): 1-12. [Review article].

  61. Manzoor, R, Malek F, Malek S#, Shin DS# (2021). Isovaline efficacy in a rat pup model of infantile spasms. NeuroReport. 32: 61-65. #Co-mentors.

  62. Hellman A, Maietta T, Clum A, Byraju K, Raviv N, Staudt MD, Jeannotte E, Ghoshal G, Shin D, Neubauer P, Williams E, Heffter T, Burdette C, Qian J, Nalwalk J, Pilitsis J (2021). Pilot study on the effects of low intensity focused ultrasound in a swine model of neuropathic pain. Journal of Neurosurgery. 135:1508-1515.

  63. Bao J, Byraju K, Patel VJ, Hellman A, Neubauer P, Burdette C, Rafferty E, Park YL, Trowbridge R, Shin DS, Pilitsis JG (2022). The effects of low intensity focused ultrasound on neuronal activity in pain processing regions in a rodent model of common peroneal nerve injury. Neuroscience Letters. 789:136882.

  64. Cotero V, Graf J, Miwa H, Hirschstein Z, Qanud K, Huerta TS, Tai N, Ding Y, Jimenez-Cowell KJ, Tomaio J-N, Song W, Deverajan A, Tsaava T, Madhavan R, Wallace K, Loghin E, Morton C, Fan Y, Kao T-J, Akhtar K, Damaraju M, Barenboim L, Maietta T, Ashe J, Tracey KJ Coleman TR, Carlo D, Shin D, Zanos S, Chavan SS, Herzo RI, Puleo C (2022). Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nature Biomedical Engineering. 6(6):683-705.

  65. Mahoney-Rafferty EC, Tucker HR, Akhtar K, Herlihy R, Audil A, Shah D, Gupta M, Kochman EM, Feustel PJ, Molho ES, Pilitsis JG, Shin DS (2023). Assessing the location, relative expression and subclass of dopamine receptors in the cerebellum of hemi-parkinsonian rats. Neuroscience. 521:1-19.

  66. Shorrock HK, Lennon CD, Aliyeva A, Davey EE, DeMeo CC, Pritchard CE, Planco L, Velez JM, Mascorro-Huamancaja, Shin DS, Cleary JD, Berglund A (2024). Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion SCAs. Brain. 147:486-504.

  67. Herlihy RA, Alicandri F, Berger H, Rehman H, Kao Y, Akhtar K, Dybas E, Mahoney-Rafferty E, Von Stein K, Kirby R, Tawfik A, Skumurski R, Feustel PJ, Molho ES, Shin DS (2024). Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats. Experimental Brain Research. 242(2):321-336.

  68. Yu A, Singh M, Pandey A, Dybas E, Agarwal A, Kao Y, Zhao G, Kao T-J, Shin DS, Chang M-C (2025). Integrating manual preprocessing with automated feature extraction for improved rodent seizure classification. Epilepsy and Behavior. Epub ahead of print.

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